Staff CV: Georges Grau

Professor Georges E GRAU, MD, PhD

Professor of Pathology & Chair of Vascular Immunology

Contact Details
Discipline of Pathology, Faculty of Medicine and Bosch Institute
Medical Foundation Building (K25)
University of Sydney
92-94 Parramatta Road
Camperdown NSW 2042
Telephone: +61 2 9036 3078
Fax: +61 2 9036 3177
Email: ggrau@med.usyd.edu.au

Professional Biography

2006 - present	Professor, Chair of Vascular Immunology, Department of Pathology, School of Medical Sciences, Faculty of Medicine, University of Sydney
1999 - 2006	Professeur des Universites (Physiologie, section 40), Universite de la Mediterranee
1998 - 1999	Research Associate, CNRS, Prof. D. Raoult, Marseille
1997 - 1998	Invited Professor, Department of Pathology, University of Regensburg
1995 - 1997	Chef de Clinique Scientifique, University of Geneva
1992	Privat - Docent (Agregation de l'Enseignement Superieur), Faculty of Medicine, University of Geneva
1991 - 1995	Maitre de'Enseignement et de Recherche at the WHO Centre and at the Department of Pathology, University of Geneva
1989 - 1991	Charge de Recherche, Departement de Pathologie, University of Geneva
1984 - 1988	Assistant en Medecine Fondamentale, Department of Pathology, University of Geneva
1984	M.D. Thesis, University of Geneva
1983	Candidate-Specialist in Internal Medicine, Universite de Liege
1982 - 1995	Research Associate, World Health Organisation, Immunology Research and Training Centre, Prof. P.H. Lambert, University of Geneva, Switzerland
1981 - 1982	Post-Doctoral Fellow, Institut de Pathologie Cellulaire, Prof. M. Bessis, Hopital du Kremlin-Bicetre, Paris, France
1979 - 1983	Resident, Department of Internal Medicine, Prof. H. van Cauwenberghe, Hopital Universitaire de Baviere, Liege
1972 - 1979	Doctor of Medicine (with High Distinction), University of Liege

Research Interests
Immunopathology of microvascular lesions, particularly of cerebral and pulmonary complications of infectious and auto-immune diseases, especially in cerebral malaria, septic shock and multiple sclerosis. Analysis of the cellular and molecular mechanisms of the interactions between microvascular endothelial cells and cells of the immune system. Experience in various in vivo and in vitro experimental systems as well as in clinical studies. More recently, focus on the neurovascular lesion of murine and human cerebral malaria, using co-culture model systems involving brain endothelium, P. falciparum infected erythrocytes, as well as circulating cells, particularly platelets and monocytes. Follow this link http://www.medfac.usyd.edu.au/news/news/2006/JanFeb/jan8.php for further information on Professor Grau's research interests.

Murine model model of of CM
Brain endothelium endothelium-centred centred cultures cultures
Pathophysiology of membrane vesiculation

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'Top 10' Publications

GRAU GE, FAJARDO LF, PIGUET PF, ALLET B, LAMBERT PH, VASSALLI P. Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria. Science 1987; 237: 1210-1212. [JIF 31.8]
PIGUET PF, GRAU GE, ALLET B, VASSALLI P. Tumor necrosis factor is an effector of skin and gut lesions of the acute phase of graft-versus-host disease. J Exp Med 1987; 166: 1280-1289. [JIF 14.5]
GRAU GE, KINDLER V, PIGUET PF, LAMBERT PH, VASSALLI P. Prevention of experimental cerebral malaria by anticytokine antibodies. IL-3 and GM-CSF are intermediates in increased TNF production and macrophage accumulation. J Exp Med 1988; 168: 1499-1504. [JIF 14.5]
GRAU GE, TAYLOR TE, MOLYNEUX ME, WIRIMA JJ, VASSALLI P, HOMMEL M, LAMBERT PH. Tumor necrosis factor and disease severity in children with falciparum malaria. N Engl J Med 1989; 320: 1586-1591. [JIF 38.5]
KINDLER V, SAPPINO AP, GRAU GE, PIGUET PF, VASSALLI P. The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection. Cell 1989; 56: 731-740. [JIF 28.3]
GRAU GE & MÄNNEL DN. TNF inhibition in sepsis. Sounding a cautionary note. Nature Med 1997; 3: 1193-1195. [JIF 31.2]
DUPORT S, ROBERT F, MULLER D, GRAU GE, PARISI L, STOPPINI L. An in vitro blood-brain barrier model: cocultures between endothelial cells and organotypic brain slice cultures. Proc Natl Acad Sci U S A 1998; 95: 1840-1845. [JIF 10.4]
HUNT NH & GRAU GE. Cytokines: accelerators and brakes in the pathogenesis of cerebral malaria. Trends Immunol 2003; 24:491-499. [JIF 13.0]
COMBES V, TAYLOR TE, JUHAN-VAGUE I, MEGE JL, MWENECHANYA J, TEMBO M, MOLYNEUX ME, GRAU GE. Circulating endothelial microparticles in Malawian children with severe falciparum malaria complicated by coma. JAMA 2004; 291: 2542-2544. [JIF 24.8]
SCHOFIELD L, GRAU GE. The immunological basis of malaria pathogenesis. Nat Rev Immunol 2005; 9:722-735. [JIF 32.6]

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Prizes & Awards Received

1984	Prize of the best thesis of the Faculty of Medicine, University of Geneva, Title: "Genetic and Immunological aspects of Experimental Thrombocytopenia"
1986	BIZOT Prize
1987	Prize of the Swiss Society of Immuno-Allergology Title: "Neuroimmunological lesions mediated by TNF in malaria"
1991	Research Carreer Award of the Prof. Dr. Max Cloetta Foundation (Zürich)
1991	International Immuno-Parasitology DENIS THIENPONT Prize. Title: "Immunopathological mechanisms in malaria: from mouse to man"
1993	Fernand TISSOT Prize
1997	Scientific Prize of the Swiss Society of Intensive Care Medicine

Current Students
PhD:
Ms Araz Boghossin
Ms Fatma El-Alaasad

2009 Honours:
Ms Beryl Wen

Professional Memberships

1980 - present	Belgian Society for Immunology
1984 - present	Swiss Society for Immunology
1991 - present	Royal Society of Tropical Medicine, London
1993 - present	Society of Leukocyte Biology, Bethesda
1993 - present	International (Washington) and European (Paris) Cytokine Society
1993 - present	Société Genevoise des Neurosciences
1994 - present	New York Academy of Sciences
2004 - present	American Society of Investigative Pathology
2006 - present	Australasian Society for Immunology