| Professor
Georges E GRAU Professor of Pathology & Chair of Vascular Immunology MD, PhD |
Professor Georges GRAU
|
Professor Georges GRAU |
Contact Details, Professional Biography, Research Interests, 'Top 10' Publications, Prizes & Awards, Research Student Supervision, Professional Memberships
Contact
Details
Department
of Pathology, Faculty of Medicine and Bosch Institute
Medical Foundation Building (K25)
University of Sydney
92-94 Parramatta Road
Camperdown NSW 2042
Telephone: +61 2 9036 3078
Fax: +61 2 9036 3177
Email: ggrau@med.usyd.edu.au
| Year | Position |
| 2006 - present | Professor, Chair of Vascular Immunology, Department of Pathology, School of Medical Sciences, Faculty of Medicine, University of Sydney |
| 1999 - 2006 | Professeur des Universites (Physiologie, section 40), Universite de la Mediterranee |
| 1998 - 1999 | Research Associate, CNRS, Prof. D. Raoult, Marseille |
| 1997 - 1998 | Invited Professor, Department of Pathology, University of Regensburg |
| 1995 - 1997 | Chef de Clinique Scientifique, University of Geneva |
| 1992 | Privat - Docent (Agregation de l'Enseignement Superieur), Faculty of Medicine, University of Geneva |
| 1991 - 1995 | Maitre de'Enseignement et de Recherche at the WHO Centre and at the Department of Pathology, University of Geneva |
| 1989 - 1991 | Charge de Recherche, Departement de Pathologie, University of Geneva |
| 1984 - 1988 | Assistant en Medecine Fondamentale, Department of Pathology, University of Geneva |
| 1984 | M.D. Thesis, University of Geneva |
| 1983 | Candidate-Specialist in Internal Medicine, Universite de Liege |
| 1982 - 1995 | Research Associate, World Health Organisation, Immunology Research and Training Centre, Prof. P.H. Lambert, University of Geneva, Switzerland |
| 1981 - 1982 | Post-Doctoral Fellow, Institut de Pathologie Cellulaire, Prof. M. Bessis, Hopital du Kremlin-Bicetre, Paris, France |
| 1979 - 1983 | Resident, Department of Internal Medicine, Prof. H. van Cauwenberghe, Hopital Universitaire de Baviere, Liege |
| 1972 - 1979 | Doctor of Medicine (with High Distinction), University of Liege |
Research Interests
Immunopathology
of microvascular lesions, particularly of cerebral and pulmonary complications
of infectious and auto-immune diseases, especially in cerebral malaria, septic
shock and multiple sclerosis. Analysis of the cellular and molecular mechanisms
of the interactions between microvascular endothelial cells and cells of the
immune system. Experience in various in vivo and in vitro
experimental systems as well as in clinical studies. More recently, focus on
the neurovascular lesion of murine and human cerebral malaria, using co-culture
model systems involving brain endothelium, P. falciparum infected erythrocytes,
as well as circulating cells, particularly platelets and monocytes. Follow this
link http://www.medfac.usyd.edu.au/news/news/2006/JanFeb/jan8.php
for further information on Professor Grau's research interests.
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Murine model model of of CM |
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Brain endothelium endothelium-centred centred cultures cultures |
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Pathophysiology of membrane vesiculation |
Click
here for more detailed research information
|
GRAU GE, FAJARDO LF, PIGUET PF, ALLET B, LAMBERT PH, VASSALLI P. Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria. Science 1987; 237: 1210-1212. [JIF 31.8] |
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PIGUET PF, GRAU GE, ALLET B, VASSALLI P. Tumor necrosis factor is an effector of skin and gut lesions of the acute phase of graft-versus-host disease. J Exp Med 1987; 166: 1280-1289. [JIF 14.5] |
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GRAU GE, KINDLER V, PIGUET PF, LAMBERT PH, VASSALLI P. Prevention of experimental cerebral malaria by anticytokine antibodies. IL-3 and GM-CSF are intermediates in increased TNF production and macrophage accumulation. J Exp Med 1988; 168: 1499-1504. [JIF 14.5] |
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GRAU GE, TAYLOR TE, MOLYNEUX ME, WIRIMA JJ, VASSALLI P, HOMMEL M, LAMBERT PH. Tumor necrosis factor and disease severity in children with falciparum malaria. N Engl J Med 1989; 320: 1586-1591. [JIF 38.5] |
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KINDLER V, SAPPINO AP, GRAU GE, PIGUET PF, VASSALLI P. The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection. Cell 1989; 56: 731-740. [JIF 28.3] |
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GRAU GE & MÄNNEL DN. TNF inhibition in sepsis. Sounding a cautionary note. Nature Med 1997; 3: 1193-1195. [JIF 31.2] |
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DUPORT S, ROBERT F, MULLER D, GRAU GE, PARISI L, STOPPINI L. An in vitro blood-brain barrier model: cocultures between endothelial cells and organotypic brain slice cultures. Proc Natl Acad Sci U S A 1998; 95: 1840-1845. [JIF 10.4] |
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HUNT NH & GRAU GE. Cytokines: accelerators and brakes in the pathogenesis of cerebral malaria. Trends Immunol 2003; 24:491-499. [JIF 13.0] |
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COMBES V, TAYLOR TE, JUHAN-VAGUE I, MEGE JL, MWENECHANYA J, TEMBO M, MOLYNEUX ME, GRAU GE. Circulating endothelial microparticles in Malawian children with severe falciparum malaria complicated by coma. JAMA 2004; 291: 2542-2544. [JIF 24.8] |
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SCHOFIELD L, GRAU GE. The immunological basis of malaria pathogenesis. Nat Rev Immunol 2005; 9:722-735. [JIF 32.6] |
Click here for access
to a full list of publications
| Year | Prize or Award |
| 1984 | Prize of the best thesis of the Faculty of Medicine, University of Geneva, Title: "Genetic and Immunological aspects of Experimental Thrombocytopenia" |
| 1986 | BIZOT Prize |
| 1987 | Prize of the Swiss Society of Immuno-Allergology Title: "Neuroimmunological lesions mediated by TNF in malaria" |
| 1991 | Research Carreer Award of the Prof. Dr. Max Cloetta Foundation (Zürich) |
| 1991 | International Immuno-Parasitology DENIS THIENPONT Prize. Title: "Immunopathological mechanisms in malaria: from mouse to man" |
| 1993 | Fernand TISSOT Prize |
| 1997 | Scientific Prize of the Swiss Society of Intensive Care Medicine |
Current
Students
PhD:
Mr
SumateAMPAWONG
Ms
KatharinaBLATT
Ms Dorothée
FAILLE
Duangdao NANTAKOMON
2007 Honours:
Ms Araz
Boghossin
Ms Fatma El-Alaasad
Ms Jacqueline
Theodora
Ms Melanie Wilson (Co-Supervisor)
| Year | Association details |
| 1980 - present | Belgian Society for Immunology |
| 1984 - present | Swiss Society for Immunology |
| 1991 - present | Royal Society of Tropical Medicine, London |
| 1993 - present | Society of Leukocyte Biology, Bethesda |
| 1993 - present | International (Washington) and European (Paris) Cytokine Society |
| 1993 - present | Société Genevoise des Neurosciences |
| 1994 - present | New York Academy of Sciences |
| 2004 - present | American Society of Investigative Pathology |
| 2006 - present | Australasian Society for Immunology |
