Staff CV: Brett Hambly

Associate Professor Brett HAMBLY, BSc(Med), MB BS, PhD, Dip Anat
Honours Coordinator

Contact Details
Room 557
Discipline of Pathology
5th Floor, Blackburn Building, D06
University of Sydney, NSW, 2006
Telephone: +61 2 9351 3059
Fax: +61 2 9351 3429
Email: bretth@med.usyd.edu.au

Professional Biography

2005 - present	Honours Coordinator
2003 - present	Associate Professor, Department of Pathology, University of Sydney
2003 - present	Adjunct Associate Professor, Biology (Molecular Biophysics), Florida State University, Tallahassee, USA
1994 - 2002	Senior Lecturer, Department of Pathology, University of Sydney
1992 - 1993	Lecturer, Department of Pathology, University of Sydney
1991	NH&MRC Senior Research Officer, Department of Anatomy, University of Sydney
1989 - 1990	NH&MRC C.J. Martin Postdoctoral Research Fellow, Department of Anatomy, University of Sydney
1987 - 1988	NH&MRC C.J. Martin Postdoctoral Research Fellow, Department of Biochemistry and Biophysics, University of California, San Francisco
1984 - 1986	Temporary Lecturer, Department of Anatomy, University of Sydney
1982 - 1984	Life Insurance Medical Research Fund of Australia and New Zealand Research Scholar (Candidate for PhD), Department of Anatomy, University of Sydney
1982 - 1984	Relief Staff - Medical, Royal Prince Alfred Hospital, Sydney
1980 - 1981	Intern and Resident Medical Officer, Royal Prince Alfred Hospital, Sydney

Research Insterests
The research programme in my laboratory has two strands: (i) determination of the molecular structure and function of proteins, using the contractile proteins as a model system, and (ii) understanding cardiovascular disease at a molecular and cellular level.

Functional effects of familial hypertrophic cardiomyopathy mutations in sarcomeric proteins
Protein degradation leading to cardiac stunning following myocardial ischaemia
Electrical instability in revascularised myocardium following myocardial infarction
Regulation of arterial smooth muscle proliferation during atherogenesis

Click here for more detailed research information

Collaborations

Functional effects of familial hypertrophic cardiomyopathy mutations in sarcomeric proteins
Collaborators: Professor Ron Trend, and Dr Bing Yu, Department of Clinical and Molecular Genetics, RPA Hospital; Professor Richmond Jeremy and Associate Professor David Richmond, Department of Cardiology, RPA Hospital
Protein degradation leading to cardiac stunning following myocardial ischaemia
Collaborator: Professor Richmond Jeremy, Department of Cardiology, RPA Hospital
Electrical instability in revascularised myocardium following myocardial infarction
Collaborator: Dr Mark McGuire, Department of Cardiology, RPA Hospital
Regulation of arterial smooth muscle proliferation during atherogenesis
Collaborator: Associate Professor Bob Bao, Mucosa Immunology Unit, Department of Pathology, University of Sydney

Grants Awarded

Functional proteomic studies of the pathogenesis of stunned myocardium, National Heart Foundation, 2004-05
Inhibition of atherosclerosis by phyto-oestrogen compounds, Novogen Pty Ltd, 2003
Pathogenesis of familial hypertrophic cardiomyopathy, National Heart Foundation, 2002-03
Proteomics Equipment, Precinct Infrastructure Grant, 2001
Inhibition of atherosclerosis by phyto-oestrogen compounds, Novogen Pty Ltd, 2000
Structural and functional alterations of sarcomeric proteins in reperfused myocardium, NH&MRC Project Grant, 2000-02
Protein defects in familial hypertrophic cardiomyopathy, National Heart Foundation, 2000-01

'Top 10' Publications

White, M.Y., Cordwell S.J., McCarron, H.C.K., Prasan, A.S., Craft, G., Hambly, B.D. and Jeremy, R.W. (2005) Proteomics of ischemia / reperfusion injury in rabbit myocardium reveals alterations to proteins of essential functional systems. Proteomics 5: 1395-1410.
Ivanovaa, E.P., Onyshchenkob, O.M., Christenc, R., Zhukovad, N.V., Lysenkoe, A.M., Shevchenkoa, L.S., Buljan, V., Hambly, B. and Kiprianova, E.A. (2005) Oceanimonas smirnovii sp. nov., a novel organism isolated from the Black Sea. Syst, Appl. Microbiol. 28: 131-136.
McLachlan, CS, Hambly, BD, Almsherqi, Z, Oakley, RE and McGuire, MA. (2006) Transfer of mouse embryonic stem cells to sheep myocardium. Lancet 367:301-2.
White, M.Y., Hambly, BD, Jeremy RW, Cordwell, SJ. (2006) Ischemia-specific phosphorylation and myofilament translocation of heat shock protein 27 precedes alpha B-crystallin and occurs independently of reactive oxygen species in rabbit myocardium. J Mol Cell Cardiol (in press, 28/2/2006).
Baumann, B., Liang, H., Sale, K., Hambly, B., and Fajer, P. (2004) Myosin Regulatory Domain Orientation in Skeletal Muscle Fibers: Application of Novel EPR Spectral Decomposition and Molecular Modeling Methods. Biophys. J. 86: 3030-3041.
Cecily E. Oakley, Brett D Hambly, Paul M.G. Curmi and Louise J. Brown. (2004) Myosin binding protein C: structural abnormalities in familial hypertrophic cardiomyopathy. Cell Research 14: 95-110
McLachlan, C.S., P.R. Jusuf, N. Rummery, S.K. Kummerfeld, B. Hambly, M.A. McGuire, and V. Turner. (2003) Tyramide signal amplification enhances the detectable distribution of connexin-43 positive gap junctions across the ventricular wall of the rabbit heart. Archives of Histology and Cytology 66: 359-365.
Jian L Yin, Brett D Hambly, Shi S Bao, Dorothy Painter, G Alex Bishop and Josette M Eris. (2003) Expression of growth arret-specific gene 6 and its receptors in dysfunctional human renal allografts. Transplant International 16: 681-8
Melanie Y White, Stuart J Cordwell, Hugh C.K. McCarron, Adrian S Tchen, Brett D Hambly and Richmond W Jeremy. (2003) Modifications of Myosin Regulatory Light Chain Correlate With Function of Stunned Myocardium. J. Mol. Cell. Cardiol. 35: 833-40.
Louise J. Brown, Leena Singh, Kenneth L. Sale, Bing Yu, Ronald Trent, Peter G. Fajer and Brett D. Hambly. (2002) Functional and spectroscopic studies of a Familial Hypertrophic Cardiomyopathy mutation in Motif X of caardiac Myosin Binding Protein-C. Eur. Biophys. J. 31: 400-8.
Ananth M Prasan, Hugh C K McCarron, Melanie Y White, Susan V McLennan, Adrian S Tchen, Brett D Hambly, Richmond W Jeremy. (2002) Duration of ischaemia determines matrix metalloproteinase-2 activation in the reperfused rabbit heart. Proteomics 2: 1204-1201
Ananth M Prasan, Hugh C K McCarron, Brett D Hambly, Gary G Fermanis, David R Sullivan, Richmond W Jeremy. (2002) Effect of treatment on ventricular function and troponin I proteolysis in reperfused myocardium. J. Mol. Cell. Cardiol. 34: 401-411.
Irina Dedova, Vadim Dedov, Neil Nosworthy, Brett D Hambly, and Cris G. dos Remedios. (2002) Cofilin and DNase I affect the conformation of the small domain of actin. Biophys. J. 82: 3134-43.
Jian L Yin, Helen Pimore, Yi Q Yan, Geoffrey McCaughan, G Alex Bishop, Brett D Hambly, Josette M Eris. (2002) Expression of growth arrest-specific gene 6 and its receptors in a rat model of chronic renal transplant rejection. Transplantation 73: 657-60.

Click here for access to a full list of publications

Prizes & Awards Received

2000	National Heart Foundation of Australia - Eleanor Gillespie Griffin Research Award
2002	National Heart Foundation of Australia - Betty Polley Research Award

Research Student Supervised to date

Honours Students: 11 Supervisor; 5 Co-Supervisor
Masters Student: 1 Supervisor
PhD Students: 3 Supervisor; 8 Co-Supervisor

Current Students
PhD Supervisor:

Mr Alistair Edwards
Ms Angie Harris
Ms Joo-Mee Hwang
Ms Komal Prabhu
Mr Adrian Tchen

2009 Honours Student:

Ms Yaxin Lu

Professional Memberships

Current	Australian Society for Biophysics Australian Medical Association Australian Society for Biochemistry & Molecular Biology US Biophysics Society National Tertiary Education Union Australian Society for Medical Research American Heart Association (Basic Sciences Council)
2001	Organising Committee (Treasurer), Workshop on Biological applications of Fluorescence Spectroscopy (attracted 110 delegates from around Australia and abroad) Organising Committee (Treasurer), Annual Conference of the Australian Society for Biophysics (National meeting of 85 delegates)
1999 - 2003	Member, Biophysics Committee, Australian Academy of Sciences State Representative on Executive, Australian Society for Biophysics
1996 - 1999	Treasurer and Executive member, Australian Society for Biophysics
1995	Organising Committee (Treasurer), Annual Conference of the Australian Society for Biophysics (National meeting of 90 delegates)